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Many people think that “hope” means something like “I sure wish (hope) something good is going to happen when_______”. The idea here is what we call wishful thinking. Wishful thinking isn’t bad, but it isn’t hope. Hope is expecting God to do something great, loving, personal in my life this moment, the next moment and every moment that I am directing hope towards. So when I am feeling any kind of dread about anything coming up, I am not “in hope”. I’ve “fallen out of hope”. The lack of hope at best leads to a loss of enthusiasm for the moment and for life and at worst leads to complete despair. Jesus wants us to experience hope at all times.
This makes powerful things change in the body; worry is the outcome of lack of hope, of forgetting to stay “in hope”. This video goes into a little more detail.